Article

JWA deficiency accelerates aging through disrupting intestinal epithelial homeostasis via Notch1/PPARγ/Stat5 axis

2022-01-21

Abstract excerpt

Aging usually suppresses the renewal and regeneration of intestinal epithelium. The imbalance of intestinal epithelial homeostasis may also be a promoter for aging. JWA responds to oxidative stress and repairs damaged DNA; it participates in multiple cellular processes like cell proliferation and differentiation. Here we identified JWA as a new aging-associated gene, whose deletion-accelerated aging in mice was re...

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Literature Corpus work: 71eb0e49-4db1-5d2c-8d9a-0d4a318aebd8
DOI: 10.1101/2022.01.17.476552

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