Article

<i>N</i> -arylpyrazole NOD2 agonists promote immune checkpoint inhibitor therapy

2023-01-27

Abstract excerpt

<h4>ABSTRACT</h4> The characterization of microbiota mechanisms in health and disease has reinvigorated pattern recognition receptors as prominent targets for immunotherapy. Notably, our recent studies on Enterococcus species revealed peptidoglycan remodeling and activation of NOD2 as key mechanisms for microbiota enhancement of immune checkpoint inhibitor therapy. Inspired by this work and other studies of NOD2...

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Literature Corpus work: 71bd9bec-cf6f-59c8-830d-c162cca5391c
DOI: 10.1101/2023.01.26.525573

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