Article

Discovery of CNS-Like D3R- Selective Antagonists Using 3D Pharmacophore Guided Virtual Screening

2018-07-23

Abstract excerpt

The dopamine D3 receptor is an important CNS target for the treatment of a variety of neurological diseases. Selective dopamine D3 receptor antagonists modulate the improvement of psychostimulant addiction and relapse. In this study, five and six featured pharmacophore models of D3R antagonists were generated and evaluated with the post-hoc score combining two survival scores of active and inactive. Among Top 10 m...

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Literature Corpus work: 71986fc3-b3fa-5ed3-b591-8ff1256b17b7
DOI: 10.20944/preprints201807.0427.v1

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