Identification of XAF1–MT2A mutual antagonism as a molecular switch in cell-fate decisions under stressful conditions

Abstract excerpt

Significance Epigenetic inactivation of XAF1 tumor suppressor is frequently observed in multiple human cancers. However, the mechanisms underlying its function remain largely undefined. Here, we present evidence that XAF1 plays a critical role in cell-fate decisions under heavy-metal–induced stress conditions through the mutual antagonism with MT2A. XAF1 is activated as a transcription target of MTF-1 and...

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