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Genetic Dysregulation of Immunologic and Oncogenic Signaling Pathways Associated with Tumor-intrinsic Immune Resistance: A Molecular Basis for Combination Targeted Therapy-Immunotherapy for Cancer

2022-10-13

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<title>Abstract</title> <p>Since the turn of the century, advances in targeted therapy and immunotherapy have revolutionized the treatment of cancer. Although these approaches have far outperformed traditional therapies in various clinical settings, both remain plagued by mechanisms of innate and acquired resistance that limit therapeutic efficacy in many patients. With a focus on tumor-intrinsic resistance to im...

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Literature Corpus work: 31bee6f4-b6d2-5168-9ebb-52508f1024c8
DOI: 10.21203/rs.3.rs-2124239/v1

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