Article

STMN1–IGFBP5 axis induces senescence and extracellular matrix degradation in nucleus pulposus cells: In vivo and in vitro insights

2025-03-27

Abstract excerpt

<title>Abstract</title> <p>Cellular dysfunction induced by senescent nucleus pulposus (NP) cells is a key factor in the pathogenesis of intervertebral disc degeneration (IDD). Stathmin 1 (STMN1) has been proposed as a telomere-associated senescence marker implicated in senescence in many age-related diseases. Nevertheless, its role in NP cell senescence remains unclear. This study revealed that STMN1 was signific...

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Literature Corpus work: 0a90861a-92e6-54d9-bf46-357c535a306f
DOI: 10.21203/rs.3.rs-5581459/v1

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