Article
Chronic Resveratrol Treatment Inhibits MRC5 Fibroblast SASP-Related Protumoral Effects on Melanoma Cells.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Sept 2017
Menicacci Beatrice, Laurenzana Anna, Chillà Anastasia, Margheri Francesca, Peppicelli Silvia, Tanganelli Elisabetta, Fibbi Gabriella, Giovannelli Lisa, Del Rosso Mario, Mocali Alessandra
Abstract excerpt
Cellular senescence is related to organismal aging and is observed after DNA damaging cancer therapies, that induce tumor-suppressive modifications, but it is characterized by a strong increase in secreted factors, termed the "senescence-associated secretory phenotype" (SASP). Particularly, SASP from stroma senescent fibroblasts creates a cancer-favoring microenvironment, providing targets for anti-cancer...
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