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Extracellular HSP90α promotes cellular senescence by modulating TGF ‐β signaling in pulmonary fibrosis

28 Jul 2022

Abstract excerpt

Recent findings suggest that extracellular heat shock protein 90α (eHSP90α) promotes pulmonary fibrosis, but the underlying mechanisms are not well understood. Aging, especially cellular senescence, is a critical risk factor for idiopathic pulmonary fibrosis (IPF). Here, we aim to investigate the role of eHSP90α on cellular senescence in IPF. Our results found that eHSP90α was upregulated in bleomycin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35899478
DOI: 10.1096/fj.202200406rr

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