Article

Modeling gene regulatory perturbations via deep learning from high-throughput reporter assays

2026-03-31

Abstract excerpt

Assessing likely variant effects on phenotypes is of critical importance in diagnostic settings, and while much progress has been made in interpreting genic mutations based on our understanding of coding sequence, noncoding variants can be much more challenging to reliably interpret based on DNA sequence alone. High-throughput reporter assays such as STARR-seq and MPRA have shown utility in experimentally measurin...

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Literature Corpus work: 8d25d483-4472-5f60-b1e7-6dd0ac805f68
DOI: 10.64898/2026.03.27.714770

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