Article

RPA directly stimulates Mer3/HFM1 helicase processivity to ensure normal crossover formation in meiosis

2025-08-02

Abstract excerpt

Meiotic crossover formation is critical for generating viable gametes and enhancing genetic diversity. The helicase Mer3 (HFM1 in humans) is a highly conserved factor essential for promoting crossovers and ensuring their proper distribution. Here, we identify replication protein A (RPA) as a direct interactor of budding yeast Mer3. We demonstrate that this interaction is conserved between human HFM1 and RPA. Cross...

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Literature Corpus work: 7128ddfc-6721-5b74-bdf4-f8bcc1aed782
DOI: 10.1101/2025.08.02.668043

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