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Article

RPA directly stimulates Mer3 helicase processivity to ensure normal crossover formation in meiosis.

Nature communications - 18 Mar 2026

Altmannova Veronika, Orlić Lucija, Carrasco Carolina, Adam Céline, Aicart-Ramos Clara, Guerrini Dario, Janning Petra, Borde Valérie, Matos Joao, Moreno-Herrero Fernando, Weir John R

Abstract excerpt

Meiotic crossover formation is critical for generating viable gametes and enhancing genetic diversity. The helicase Mer3 (HFM1 in humans) is a highly conserved factor essential for promoting crossovers and ensuring their proper distribution. Here, we identify replication protein A (RPA) as a direct interactor of budding yeast Mer3. We demonstrate that this interaction is conserved between human HFM1 and RPA....

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Share to Crossing Over, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41851108
DOI: 10.1038/s41467-026-69985-x
PMCID: PMC13003030

Genes

HFM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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