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Article

Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer.

Handbook of experimental pharmacology - 1 Jan 2018

Betancor-Fernández Isabel, Timson David J, Salido Eduardo, Pey Angel L

Abstract excerpt

Mutations causing single amino acid exchanges can dramatically affect protein stability and function, leading to disease. In this chapter, we will focus on several representative cases in which such mutations affect protein stability and function leading to cancer. Mutations in BRAF and p53 have been extensively characterized as paradigms of loss-of-function/gain-of-function mechanisms found in a remarkably large...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NAD(P)H Dehydrogenase (Quinone)

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 28993836
DOI: 10.1007/164_2017_55

Genes

BRAF
NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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