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Article

Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface

1 May 2019

Abstract excerpt

During pregnancy, maternal regulatory T cells (Tregs) are important in establishing immune tolerance to invading fetal extravillous trophoblasts (EVTs). CD25 HI FOXP3+ Tregs are found at high levels in decidual tissues and have been shown to suppress fetus-specific and nonspecific responses. However, limited data are available on additional decidual Treg types and the mechanisms by which they are induced. This...

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PMID: 31141680
DOI: 10.1016/j.celrep.2019.04.109

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