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Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies

11 Apr 2023

Abstract excerpt

The authors of a recent study identified noncanonical peptides (NCP) presented by cancer cells' HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers tested, providing opportunities for novel therapies to shared antigens. See related article by Lozano-Rabella et al.,...

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PMID: 37040070
DOI: 10.1158/1078-0432.ccr-23-0422

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