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Immunogenic cryptic peptides dominate the antigenic landscape of ovarian cancer

19 Feb 2025

Abstract excerpt

Increased infiltration of CD3 + and CD8 + T cells into ovarian cancer (OC) is linked to better prognosis, but the specific antigens involved are unclear. Recent reports suggest that HLA class I can present peptides from noncoding genomic regions, known as noncanonical or cryptic peptides, but their immunogenicity is underexplored. To address this, we used immunopeptidomic analysis and RNA sequencing on five...

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PMID: 39970218
DOI: 10.1126/sciadv.ads7405

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