Article

Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations

2024-12-16

Abstract excerpt

Many agents that show promise in preclinical cancer models lack efficacy in patients due to patient heterogeneity that is not captured in traditional assays. To address this problem, we have developed GENEVA, a platform that measures the molecular and phenotypic consequences of drug perturbations within diverse populations of cancer cells at single-cell resolution, both in vitro and in vivo . Here, we apply GENE...

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Literature Corpus work: 70d11d6a-25fd-523b-b3db-1af6da2c0d80
DOI: 10.1101/2024.12.13.628239

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