Article

The G-protein coupled receptor OXER1 is a tissue redox sensor essential for intestinal epithelial barrier integrity

2025-02-08

Abstract excerpt

Generation of reactive oxygen species is an important part of the innate immune response. Generating microbicidal levels of reactive oxygen species (ROS) requires adaptation of mucosal barriers. High tolerance of ROS provides improved innate immune defenses against pathogens, whereas low tolerance renders host cells prone to chronic toxicity and mutagenesis, which can promote inflammation (e.g., in asthma and Croh...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 70b55e27-8f46-533b-a4e8-64df452a426c
DOI: 10.1101/2025.02.05.636712

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The G-protein coupled receptor OXER1 is a tissue redox sensor essential for intestinal epithelial barrier integrityDOI 10.1101/2025.02.05.636712Read

DHRS7 Integrates NADP <sup>+</sup> /NADPH Redox Sensing with Inflammatory Lipid Signalling via the Oxoeicosanoid PathwaySemantic proximity Read

Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel diseaseSemantic proximity Read

Peds1 deficiency in zebrafish results in myeloid cell apoptosis and exacerbated inflammationSemantic proximity Read

Zebrafish Oxr1a Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging.Semantic proximity Read

Annexin A1 regulates intestinal mucosal injury, inflammation, and repair.Semantic proximity Read

Complex responses to inflammatory oxidants by the probiotic bacterium <i>Lactobacillus reuteri</i>Semantic proximity Read

The gut lactic acid bacteria metabolite, 10-oxo- <i>cis</i> -6, <i>trans</i> -11-octadecadienoic acid, suppresses inflammatory bowel disease in mice by modulating the NRF2 pathway and GPCR-signalingSemantic proximity Read

Transcription factor EB modulates the homeostasis of reactive oxygen species in intestinal epithelial cells to alleviate inflammatory bowel diseaseSemantic proximity Read

5,6-Epoxycholestanols Metabolism and Functions: Defining the Epoxycholestanoid (EChA) FamilySemantic proximity Read

A Genetic Analysis of the Caenorhabditis elegans Detoxification Response.Semantic proximity Read

The 1 -Cys peroxiredoxin, PRDX-6, suppresses an NHR-49-dependent pro-survival response, including the Flavin monooxygenase, FMO-2, that protects against fungal and bacterial infection.Semantic proximity Read

The epithelial-specific ER stress sensor ERN2/IRE1β enables host-microbiota crosstalk to affect colon goblet cell developmentSemantic proximity Read