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Zebrafish Oxr1a Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging.

Genes - 24 Sept 2020

Xu Hao, Jiang Yu, Li Sheng, Xie Lang, Tao Yi-Xi, Li Yun

Abstract excerpt

Oxidation resistance gene 1 (OXR1) is essential for protection against oxidative stress in mammals, but its functions in non-mammalian vertebrates, especially in fish, remain uncertain. Here, we created a homozygous oxr1a-knockout zebrafish via the CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein 9) system. Compared with wild-type (WT) zebrafish, oxr1a-/- mutants...

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Identifiers

PMID: 32987694
DOI: 10.3390/genes11101118
PMCID: PMC7598701

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