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Article

Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence

1 Nov 2023

Abstract excerpt

Oncogene-induced senescence (OIS) is a persistent anti-proliferative response that acts as a barrier against malignant transformation. During OIS, cells undergo dynamic remodeling, which involves alterations in protein and organelle homeostasis through autophagy. Here, we show that ribosomes are selectively targeted for degradation by autophagy during OIS. By characterizing senescence-dependent alterations in the...

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PMID: 37930887
DOI: 10.1016/j.celrep.2023.113381

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