Article
Prc protease promotes mucoidy in mucA mutants of Pseudomonas aeruginosa.
Microbiology (Reading, England) - 1 Jul 2005
Reiling S A, Jansen J A, Henley B J, Singh S, Chattin C, Chandler M, Rowen D W
Abstract excerpt
Mucoid strains of Pseudomonas aeruginosa that overproduce the exopolysaccharide alginate are a frequent cause of chronic respiratory infections in cystic fibrosis (CF) patients. The overproduction of alginate by these strains is often caused by mutations within mucA of the algU mucABCD gene cluster. This gene cluster encodes an extreme stress response system composed of the ECF alternative sigma factor AlgU, the...
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