Article

Genome-wide association study for residualized-apolipoprotein B elucidates the role of apolipoprotein B in coronary artery disease risk

2025-12-15

Abstract excerpt

Apolipoprotein B (apoB) has emerged as a more accurate predictor of coronary artery disease risk relative to standard lipid measurements like low-density lipoprotein cholesterol (LDL-C). Here, we sought to characterize the clinical associations and genetics underlying apoB and LDL-C discordance. We derived a residualized-apoB phenotype, defined as observed minus expected apoB for an individual given their LDL-C le...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 708bc408-b1a3-521f-ac98-a2248c053df1
DOI: 10.64898/2025.12.11.25341921

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study for residualized-apolipoprotein B elucidates the role of apolipoprotein B in coronary artery disease riskDOI 10.64898/2025.12.11.25341921Read

Low-Density Lipoprotein Cholesterol, Apolipoprotein B, and Risk of Coronary Heart DiseaseSemantic proximity Read

Phenotypic and Genetic Characterization of Lower LDL Cholesterol and Increased Type 2 Diabetes Risk in the UK Biobank.Semantic proximity Read

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.Semantic proximity Read

Prevalence of Dysbetalipoproteinemia in the UK Biobank According to Different Diagnostic CriteriaSemantic proximity Read

Apolipoprotein B levels, APOB alleles, and risk of ischemic cardiovascular disease in the general population, a review.Semantic proximity Read

Cardiovascular events in individuals with small/medium LDL particle discordanceSemantic proximity Read

APOB to estimated APOB ratio for screening for the APOE2 genotypeSemantic proximity Read

A potentially underestimated predictor of coronary artery disease risk: The ApoB/ApoA1 ratioSemantic proximity Read

Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles.Semantic proximity Read

Rare Protein-Truncating Variants in APOB , Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart DiseaseSemantic proximity Read

Discordance analysis of apolipoprotein B and non-high density lipoprotein cholesterol as markers of cardiovascular risk in the INTERHEART study.Semantic proximity Read

Population-based resequencing of APOA1 in 10,330 individuals: spectrum of genetic variation, phenotype, and comparison with extreme phenotype approach.Semantic proximity Read