Article
Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting.
Blood - 16 Jun 2016
He Jie, Abdel-Wahab Omar, Nahas Michelle K, Wang Kai, Rampal Raajit K, Intlekofer Andrew M, Patel Jay, Krivstov Andrei, Frampton Garrett M, Young Lauren E, Zhong Shan, Bailey Mark, White Jared R, Roels Steven, Deffenbaugh Jason, Fichtenholtz Alex, Brennan Timothy, Rosenzweig Mark, Pelak Kimberly, Knapp Kristina M, Brennan Kristina W, Donahue Amy L, Young Geneva, Garcia Lazaro, Beckstrom Selmira T, Zhao Mandy, White Emily, Banning Vera, Buell Jamie, Iwanik Kiel, Ross Jeffrey S, Morosini Deborah, Younes Anas, Hanash Alan M, Paietta Elisabeth, Roberts Kathryn, Mullighan Charles, Dogan Ahmet, Armstrong Scott A, Mughal Tariq, Vergilio Jo-Anne, Labrecque Elaine, Erlich Rachel, Vietz Christine, Yelensky Roman, Stephens Philip J, Miller Vincent A, van den Brink Marcel R M, Otto Geoff A, Lipson Doron, Levine Ross L
Abstract excerpt
The spectrum of somatic alterations in hematologic malignancies includes substitutions, insertions/deletions (indels), copy number alterations (CNAs), and a wide range of gene fusions; no current clinically available single assay captures the different types of alterations. We developed a novel next-generation sequencing-based assay to identify all classes of genomic alterations using archived formalin-fixed...
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