Article
Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice.
Nature communications - 10 Aug 2023
Rosenberg Ayelet M, Saggar Manish, Monzel Anna S, Devine Jack, Rogu Peter, Limoges Aaron, Junker Alex, Sandi Carmen, Mosharov Eugene V, Dumitriu Dani, Anacker Christoph, Picard Martin
Abstract excerpt
The brain and behavior are under energetic constraints, limited by mitochondrial energy transformation capacity. However, the mitochondria-behavior relationship has not been systematically studied at a brain-wide scale. Here we examined the association between multiple features of mitochondrial respiratory chain capacity and stress-related behaviors in male mice with diverse behavioral phenotypes. Miniaturized...
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