Article

Reconstructing physiological oxygen gradients reveals the role of hypoxia in colon epithelial organization

2025-12-19

Abstract excerpt

Oxygen gradients organize tissue architecture and metabolism 1,2 , yet their precise spatial profiles and mechanistic roles remain poorly understood because both in vivo measurement and in vitro control are technically challenging 3,4 . Here, we quantify the oxygen landscape of the mammalian intestine using microscale sensors, revealing a steep luminal–basal gradient of approximately 10-60 µM mm − 1 that coll...

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Literature Corpus work: 70634484-2a2a-5e38-a351-aaee9a3a38b6
DOI: 10.64898/2025.12.16.694730

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