Article

Establishment of physiologically relevant oxygen gradients in microfluidic organ chips

2022-01-30

Abstract excerpt

In vitro models of human organs must accurately reconstitute oxygen concentrations and gradients that are observed in vivo to mimic gene expression, metabolism, and host-microbiome interactions. Here we describe a simple strategy to achieve physiologically relevant oxygen tension in a two-channel human small intestine-on-a-chip (Intestine Chip) lined with primary human duodenal epithelium and intestinal microvasc...

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Literature Corpus work: 1332e415-2ec7-5006-bbb2-57015150a1d0
DOI: 10.1101/2022.01.29.478323

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