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Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits

16 Nov 2010

Abstract excerpt

We report the use of thin film poly(dimethylsiloxane) (PDMS) prints for the arrayed mass production of highly uniform 3-D human HT29 colon carcinoma spheroids. The spheroids have an organotypic density and, as determined by 3-axis imaging, were genuinely spherical. Critically, the array density impacts growth kinetics and can be tuned to produce spheroids ranging in diameter from 200 to 550 µm. The diffusive...

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PMID: 21079873
DOI: 10.1039/c0lc00089b

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