Article
Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.
Nature genetics - 1 Apr 2020
Lin Kevin H, Rutter Justine C, Xie Abigail, Pardieu Bryann, Winn Emily T, Bello Reinaldo Dal, Forget Antoine, Itzykson Raphael, Ahn Yeong-Ran, Dai Ziwei, Sobhan Raiyan T, Anderson Gray R, Singleton Katherine R, Decker Amy E, Winter Peter S, Locasale Jason W, Crawford Lorin, Puissant Alexandre, Wood Kris C
Abstract excerpt
Local adaptation directs populations towards environment-specific fitness maxima through acquisition of positively selected traits. However, rapid environmental changes can identify hidden fitness trade-offs that turn adaptation into maladaptation, resulting in evolutionary traps. Cancer, a disease that is prone to drug resistance, is in principle susceptible to such traps. We therefore performed pooled...
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