Article

NOTCH3 signalling controls human trophoblast stem cell expansion and differentiation

2023-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Failures in growth and differentiation of the early human placenta are associated with severe pregnancy disorders such as preeclampsia and fetal growth restriction. However, regulatory mechanisms controlling development of its epithelial cells, the trophoblasts, remain poorly elucidated. Using trophoblast stem cells (TSCs), trophoblast organoids (TB-ORGs) and primary cytotrophoblasts (CTBs) of e...

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Literature Corpus work: 7045a09f-a782-511e-8291-93567a480c14
DOI: 10.1101/2023.07.03.547490

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