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Article

WNT and NOTCH signaling in human trophoblast development and differentiation

13 May 2022

Abstract excerpt

Correct development of the human placenta and its differentiated epithelial cells, syncytial trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful pregnancy outcome. STBs develop by cell fusion of mononuclear cytotrophoblasts (CTBs) in placental floating villi, whereas migratory EVTs originate from specialized villi anchoring to the maternal decidua. Defects in trophoblast...

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PMID: 35562545
DOI: 10.1007/s00018-022-04285-3

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