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NOTCH3 signalling controls human trophoblast stem cell expansion and differentiation

31 Oct 2023

Abstract excerpt

Failures in growth and differentiation of the early human placenta are associated with severe pregnancy disorders such as pre-eclampsia and fetal growth restriction. However, regulatory mechanisms controlling development of placental epithelial cells, the trophoblasts, remain poorly elucidated. Using trophoblast stem cells (TSCs), trophoblast organoids (TB-ORGs) and primary cytotrophoblasts (CTBs) of early...

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PMID: 37905445
DOI: 10.1242/dev.202152

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