Article

HuR Regulates GATA3-Driven Type 2 Inflammation in CD4⁺ T cells and ILC2 in Airway Inflammation

2026-04-27

Abstract excerpt

Type 2 high asthma is driven by coordinated GATA3 dependent programs in CD4 + T cells and group 2 innate lymphoid cells (ILC2). Although biologics targeting IL4, IL5, or IL13 benefit subsets of patients, many remain symptomatic, suggesting that upstream regulatory mechanisms may sustain type 2 inflammation. We investigated whether HuR (ELAVL1), an RNA-binding protein that stabilizes GATA3 and Th2 cytokines mRNA,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 702e597a-dd10-591d-a9ec-0fc6d5d49b86
DOI: 10.64898/2026.04.23.720195

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HuR Regulates GATA3-Driven Type 2 Inflammation in CD4⁺ T cells and ILC2 in Airway InflammationDOI 10.64898/2026.04.23.720195Read

RNA-binding protein RBM3 negatively regulates innate lymphoid cells (ILCs) and lung inflammationSemantic proximity Read

RNA-binding protein RBM3 negatively regulates innate lymphoid cells (ILCs) and lung inflammationSemantic proximity Read

Single-cell profiling uncovers regulatory programs of pathogenic Th2 cells in allergic asthmaSemantic proximity Read

Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 CellsSemantic proximity Read

Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthmaSemantic proximity Read

Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility.Semantic proximity Read

IL-6 Production Through Repression of UBASH3A Gene via Epigenetic Dysregulation of Super-Enhancer in CD4+T Cells in Rheumatoid ArthritisSemantic proximity Read

Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiationSemantic proximity Read

Single-cell Analysis of TFH Cell Subsets in Allergic Rhinitis: Discovery of the GZMK+ TFH Cell SubsetSemantic proximity Read

The RNA‐binding protein HuR/ELAVL1 regulates IFN‐β mRNA abundance and the type I IFN responseSemantic proximity Read

Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbationsSemantic proximity Read

Posttranscriptional Gene Regulation of IL-17 by the RNA-Binding Protein HuR Is Required for Initiation of Experimental Autoimmune EncephalomyelitisSemantic proximity Read