Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation

17 Dec 2012

Abstract excerpt

The Th2 locus control region (LCR) has been shown to be important in efficient and coordinated cytokine gene regulation during Th2 cell differentiation. However, the molecular mechanism for this is poorly understood. To study the molecular mechanism of the Th2 LCR, we searched for proteins binding to it. We discovered that transcription factor YY1 bound to the LCR and the entire Th2 cytokine locus in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23248301
DOI: 10.1073/pnas.1214682110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiationPMID 23248301Read ↗

Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthmaSemantic proximity Read ↗

Yin yang 1: a potential regulator of immune related diseases and cancer immunitySemantic proximity Read ↗

Comprehensive mapping of the human cytokine gene regulatory networkSemantic proximity Read ↗

Chromatin remodeling and T helper subset differentiation.Semantic proximity Read ↗

Convergent Evidence Supports TH2LCRR as a Novel Asthma Susceptibility Gene.Semantic proximity Read ↗

Transcriptional regulation of Th2 cell differentiationSemantic proximity Read ↗

HuR Regulates GATA3-Driven Type 2 Inflammation in CD4⁺ T cells and ILC2 in Airway InflammationSemantic proximity Read ↗

YY1 as a regulator of replication-dependent hamster histone H3.2 promoter and an interactive partner of AP-2.Semantic proximity Read ↗

TERC promotes cellular inflammatory response independent of telomeraseSemantic proximity Read ↗

An Upstream YY1 Binding Site on the HIV-1 LTR Contributes to Latent InfectionSemantic proximity Read ↗

Identification of global regulators of T-helper cell lineage specificationSemantic proximity Read ↗

LncRNA STAT4-AS1 inhibited TH17 cells differentiation by targeting RORγt proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.