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Article

Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity.

PloS one - 1 Jan 2016

Flores Brittany N, Dulchavsky Mark E, Krans Amy, Sawaya Michael R, Paulson Henry L, Todd Peter K, Barmada Sami J, Ivanova Magdalena I

Abstract excerpt

Hexanucleotide repeat expansions in C9orf72 are the most common inherited cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The expansions elicit toxicity in part through repeat-associated non-AUG (RAN) translation of the intronic (GGGGCC)n sequence into dipeptide repeat-containing proteins (DPRs). Little is known, however, about the structural characteristics and aggregation...

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Identifiers

PMID: 27776165
DOI: 10.1371/journal.pone.0165084
PMCID: PMC5077081

Genes

RAN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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