Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Shared Genetic Signature for Common Chronic Pain Conditions and its Impact on Biopsychosocial Traits.

The journal of pain - 1 Mar 2023

Farrell Scott F, Kho Pik-Fang, Lundberg Mischa, Campos Adrián I, Rentería Miguel E, de Zoete Rutger M J, Sterling Michele, Ngo Trung Thanh, Cuéllar-Partida Gabriel

Abstract excerpt

The multiple comorbidities & dimensions of chronic pain present a formidable challenge in disentangling its aetiology. Here, we performed genome-wide association studies of 8 chronic pain types using UK Biobank data (N =4,037-79,089 cases; N = 239,125 controls), followed by bivariate linkage disequilibrium-score regression and latent causal variable analyses to determine (respectively) their genetic correlations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Disease
Share to Chronic Pain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comorbidity

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 36252619
DOI: 10.1016/j.jpain.2022.10.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Shared Genetic Signature for Common Chronic Pain Conditions and its Impact on Biopsychosocial Traits.PMID 36252619Read ↗

A shared genetic signature for common chronic pain conditions and its impact on biopsychosocial traitsSemantic proximity Read ↗

Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modelingSemantic proximity Read ↗

A Data-Driven Biopsychosocial Framework Determining the Spreading of Chronic PainSemantic proximity Read ↗

Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits.Semantic proximity Read ↗

A multi-trait approach improves polygenic risk scores for chronic back pain across population-based and clinically ascertained samplesSemantic proximity Read ↗

Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain at different anatomic sitesSemantic proximity Read ↗

Genome-wide association study of multisite chronic pain in UK BiobankSemantic proximity Read ↗

Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain conditions.Semantic proximity Read ↗

Rare variant associations of chronic pain conditions in the UK Biobank Whole Exome SequencingSemantic proximity Read ↗

Genetic and epigenetic epidemiology of chronic widespread painSemantic proximity Read ↗

Development and Replication of a Genome-Wide Polygenic Risk Score for Chronic Back PainSemantic proximity Read ↗

Shared genetic factors underlie chronic pain syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.