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Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank.

PLoS genetics - 1 Apr 2021

Johnston Keira J A, Ward Joey, Ray Pradipta R, Adams Mark J, McIntosh Andrew M, Smith Blair H, Strawbridge Rona J, Price Theodore J, Smith Daniel J, Nicholl Barbara I, Bailey Mark E S

Abstract excerpt

Chronic pain is highly prevalent worldwide and imparts a significant socioeconomic and public health burden. Factors influencing susceptibility to, and mechanisms of, chronic pain development, are not fully understood, but sex is thought to play a significant role, and chronic pain is more prevalent in women than in men. To investigate sex differences in chronic pain, we carried out a sex-stratified genome-wide...

Topics

Biological Specimen Banks
Chronic Pain
Female
Genetic Predisposition to Disease
Genetic Testing
Genome-Wide Association Study
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sex Characteristics

United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 33830993
DOI: 10.1371/journal.pgen.1009428
PMCID: PMC8031124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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