Article
Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain conditions.
Communications biology - 25 Jun 2020
Tsepilov Yakov A, Freidin Maxim B, Shadrina Alexandra S, Sharapov Sodbo Z, Elgaeva Elizaveta E, Zundert Jan van, Karssen Lennart С, Suri Pradeep, Williams Frances M K, Aulchenko Yurii S
Abstract excerpt
Chronic musculoskeletal pain affects all aspects of human life. However, mechanisms of its genetic control remain poorly understood. Genetic studies of pain are complicated by the high complexity and heterogeneity of pain phenotypes. Here, we apply principal component analysis to reduce phenotype heterogeneity of chronic musculoskeletal pain at four locations: the back, neck/shoulder, hip, and knee. Using...
Topics
- Adult
- Aged
- Arthralgia
- Back Pain
- Chronic Pain
- Female
- Genetic Association Studies
- Genetic Loci
- Genetic Pleiotropy
- Genome-Wide Association Study