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Genome-wide Survey of Tandem Repeats by Nanopore Sequencing Shows that Disease-associated Repeats are More Polymorphic in the General Population

2020-10-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Tandem repeats are highly mutable and contribute to the development of human disease by a variety of mechanisms. It is difficult to predict which tandem repeats may cause a disease. One hypothesis is that changeable tandem repeats are the source of genetic diseases, because disease-causing repeats are polymorphic in healthy individuals. However, it is not clear...

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Literature Corpus work
90b39ec2-3883-5985-8acc-2bc3b94938d4
DOI
10.21203/rs.3.rs-79348/v1
Open publication

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Genome-wide Survey of Tandem Repeats by Nanopore Sequencing Shows that Disease-associated Repeats are More Polymorphic in the&nbsp;General PopulationDOI 10.21203/rs.3.rs-79348/v1
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