Article

The genetic basis and evolution of red blood cell sickling in deer

2017-06-26

Abstract excerpt

Crescent-shaped red blood cells, the hallmark of sickle cell disease, present a striking departure from the biconcave disc shape normally found in mammals. Characterized by increased mechanical fragility, sickled cells promote haemolytic anaemia and vaso-occlusions and contribute directly to disease in humans. Remarkably, a similar sickle-shaped morphology has been observed in erythrocytes from several deer specie...

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Literature Corpus work: 6fd9cfc4-21b2-5d95-842b-b22afc6530a8
DOI: 10.1101/155903

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