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Article

Creatine biosynthesis and transport in health and disease.

Biochimie - 1 Dec 2015

Joncquel-Chevalier Curt Marie, Voicu Pia-Manuela, Fontaine Monique, Dessein Anne-Frédérique, Porchet Nicole, Mention-Mulliez Karine, Dobbelaere Dries, Soto-Ares Gustavo, Cheillan David, Vamecq Joseph

Abstract excerpt

Creatine is physiologically provided equally by diet and by endogenous synthesis from arginine and glycine with successive involvements of arginine glycine amidinotransferase [AGAT] and guanidinoacetate methyl transferase [GAMT]. A specific plasma membrane transporter, creatine transporter [CRTR] (SLC6A8), further enables cells to incorporate creatine and through uptake of its precursor, guanidinoacetate, also...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26542286
DOI: 10.1016/j.biochi.2015.10.022

Genes

GAMT
GATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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