Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glutamate and α-ketoglutarate: key players in glioma metabolism.

Amino acids - 1 Jan 2017

Maus Andreas, Peters Godefridus J

Abstract excerpt

Glioblastoma multiforme (GBM), or grade IV astrocytoma, is the most common type of primary brain tumor. It has a devastating prognosis with a 2-year-overall survival rate of only 26 % after standard treatment, which includes surgery, radiation, and adjuvant chemotherapy with temozolomide. Also lower grade gliomas are difficult to treat, because they diffusely spread into the brain, where extensive removal of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Citric Acid Cycle
Share to Glioblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to Isocitrate Dehydrogenase

Share to Ketoglutaric Acids

Share to Neoplasm Grading

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 27752843
DOI: 10.1007/s00726-016-2342-9
PMCID: PMC5241329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutamate and α-ketoglutarate: key players in glioma metabolism.PMID 27752843Read ↗

Glutamate dehydrogenase (GDH) regulates bioenergetics and redox homeostasis in human gliomaSemantic proximity Read ↗

A map of the altered glioma metabolism.Semantic proximity Read ↗

Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical IndicationsSemantic proximity Read ↗

Metabolism of glioma and IDH1/IDH2 mutations.Semantic proximity Read ↗

Altered cancer cell metabolism in gliomas with mutant IDH1 or IDH2.Semantic proximity Read ↗

Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations.Semantic proximity Read ↗

Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma.Semantic proximity Read ↗

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.Semantic proximity Read ↗

Cancer metabolism as a central driving force of glioma pathogenesis.Semantic proximity Read ↗

Metabolic Signaling Cascades Prompted by Glutaminolysis in CancerSemantic proximity Read ↗

Targeting distinct amino acid metabolic vulnerabilities in IDH-mutant and IDH-wildtype gliomas.Semantic proximity Read ↗

Cell biology-metabolic crosstalk in glioma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.