Article

Ultra-high efficiency T cell reprogramming at multiple loci with SEED-Selection

2024-02-07

Abstract excerpt

Multiplexed reprogramming of T cell specificity and function can generate powerful next-generation cellular therapies. However, current manufacturing methods produce heterogenous mixtures of partially engineered cells. Here, we develop a one-step process to enrich for unlabeled cells with knock-ins at multiple target loci using a family of repair templates named S ynthetic E xon/ E xpression Disruptors (SEEDs)....

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Literature Corpus work: 6fc915cc-762e-5eef-a782-43049e74f89b
DOI: 10.1101/2024.02.06.576175

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