Article

Discovery, Characterization, and Bioactivity of the Achromonodins: Lasso Peptides Encoded by <i>Achromobacter</i>

2023-06-22

Abstract excerpt

Through genome mining efforts, we discovered two lasso peptide biosynthetic gene clusters (BGCs) within two different species of Achromobacter , a genus that contains pathogenic organisms that can infect patients with cystic fibrosis. Using gene-refactored BGCs in E. coli , we heterologously expressed two lasso peptides, which we named achromonodin-1 and achromonodin-2. Achromonodin-1 is naturally encoded by cer...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 29495b40-2667-5910-b4c8-d712d261cd8f
DOI: 10.1101/2023.06.21.545946

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery, Characterization, and Bioactivity of the Achromonodins: Lasso Peptides Encoded by <i>Achromobacter</i>DOI 10.1101/2023.06.21.545946Read

Discovery, Characterization, and Bioactivity of the Achromonodins: Lasso Peptides Encoded by AchromobacterSemantic proximity Read

A Broad Spectrum Lasso Peptide Antibiotic Targeting the Bacterial RibosomeSemantic proximity Read

Investigation of the Biosynthesis of the Lasso Peptide Chaxapeptin Using an E. coli-Based Production System.Semantic proximity Read

<i>Burkholderia</i> collagen-like protein 8, Bucl8, is a unique outer membrane component of a tetrapartite efflux pump in <i>Burkholderia pseudomallei</i> and <i>Burkholderia mallei</i>Semantic proximity Read

A High-Throughput Screen Reveals the Structure-Activity Relationship of the Antimicrobial Lasso Peptide UbonodinSemantic proximity Read

Cell-Free Biosynthesis to Evaluate Lasso Peptide Formation and Enzyme-Substrate ToleranceSemantic proximity Read

Discovery of Ubonodin, an Antimicrobial Lasso Peptide Active against Members of the Burkholderia cepacia ComplexSemantic proximity Read

Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria.Semantic proximity Read

Genome mining identifies a diversity of natural product biosynthetic capacity in human respiratory Corynebacterium strainsSemantic proximity Read

The Anti- <i>Burkholderia</i> Lasso Peptide Ubonodin Co-Opts the Siderophore Receptor PupB for Cellular EntrySemantic proximity Read

<i>In silico</i> Identification of Novel Common Drug Targets Against Four Infectious <i>Acinetobacter</i> SpeciesSemantic proximity Read

Amycomicin: a potent and specific antibiotic discovered with a targeted interaction screenSemantic proximity Read