Article
Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Dec 2001
Laforet G A, Sapp E, Chase K, McIntyre C, Boyce F M, Campbell M, Cadigan B A, Warzecki L, Tagle D A, Reddy P H, Cepeda C, Calvert C R, Jokel E S, Klapstein G J, Ariano M A, Levine M S, DiFiglia M, Aronin N
Abstract excerpt
Neurons in Huntington's disease exhibit selective morphological and subcellular alterations in the striatum and cortex. The link between these neuronal changes and behavioral abnormalities is unclear. We investigated relationships between essential neuronal changes that predict motor impairment and possible involvement of the corticostriatal pathway in developing behavioral phenotypes. We therefore generated...
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