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Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer

24 Apr 2018

Abstract excerpt

Abstract Human deep space and planetary travel is limited by uncertainties regarding the health risks associated with exposure to galactic cosmic radiation (GCR), and in particular the high linear energy transfer (LET), heavy ion component. Here we assessed the impact of two high-LET ions 56Fe and 28Si, and low-LET X rays on genome-wide methylation patterns in human bronchial epithelial cells. We found that all...

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PMID: 29712937
DOI: 10.1038/s41598-018-24755-8

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