Article
Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway.
Cancer research - 15 Apr 2017
Wang Meng, Han Jing, Marcar Lynnette, Black Josh, Liu Qi, Li Xiangyong, Nagulapalli Kshithija, Sequist Lecia V, Mak Raymond H, Benes Cyril H, Hong Theodore S, Gurtner Kristin, Krause Mechthild, Baumann Michael, Kang Jing X, Whetstine Johnathan R, Willers Henning
Abstract excerpt
Lung cancers with activating KRAS mutations are characterized by treatment resistance and poor prognosis. In particular, the basis for their resistance to radiation therapy is poorly understood. Here, we describe a radiation resistance phenotype conferred by a stem-like subpopulation characterized by mitosis-like condensed chromatin (MLCC), high CD133 expression, invasive potential, and tumor-initiating...
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