Article

Cardiomyocyte antisense transcription regulates exon usage in the elastic spring region of Titin to modulate sarcomere function

2024-07-11

Abstract excerpt

<h4>Background</h4> The spring-like sarcomere protein Titin (TTN) is a key determinant of cardiac passive stiffness and diastolic function. Alternative splicing of TTN I-band exons produce protein isoforms with variable size and elasticity, but the mechanisms regulating TTN exon skipping and isoform composition in the human heart are not well studied. Non-coding RNA transcripts from the antisense strand of protei...

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Literature Corpus work: b746821d-d795-52db-a055-50e9fcfb1a08
DOI: 10.1101/2024.07.10.602998

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