Article

Activated Cancer-Associated Fibroblasts Correlate with Poor Survival and Decreased Lymphocyte Infiltration in Infiltrative Type Distal Cholangiocarcinoma

2025-04-10

Abstract excerpt

<title>Abstract</title> <p>Cancer-associated fibroblasts promote tumor progression through growth facilitation, invasion, and immune evasion. This study investigated the impact of activated cancer-associated fibroblasts (aCAFs) on survival outcomes, immune response, and molecular pathways in distal bile duct (DBD) cancer. We analyzed 469 patients (418 from our cohort and 51 from The Cancer Genome Atlas) with DBD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f85d38b-f8a7-5ab5-87bb-4b335837162f
DOI: 10.21203/rs.3.rs-5957452/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activated Cancer-Associated Fibroblasts Correlate with Poor Survival and Decreased Lymphocyte Infiltration in Infiltrative Type Distal CholangiocarcinomaDOI 10.21203/rs.3.rs-5957452/v1Read

Heterogeneity, crosstalk, and targeting of cancer-associated fibroblasts in cholangiocarcinomaSemantic proximity Read

CInvestigating the Mechanism of the Co - regulation of Colorectal Cancer by Tumor - associated Fibroblasts and Disulfidptosis Based on Single - cell RNA Sequencing and Bulk RNA SequencingSemantic proximity Read

NFATC2 in pancreatic cancer-associated fibroblasts predicts treatment response and facilitates ERBB-targeted therapiesSemantic proximity Read

Identification of Cholangiocarcinoma (CCA) Subtype-Specific BiomarkersSemantic proximity Read

The Impact of Cancer-Associated Fibroblasts on the Biology and Progression of Colorectal CarcinomasSemantic proximity Read

CXCL12 derived from cancer-associated fibroblasts mediates dysfunctional intratumoral adaptive immunity in diabetic pancreatic adenocarcinomaSemantic proximity Read

BNIP3 + cancer-associated fibroblasts and their associated genes are accelerators of pancreatic cancerSemantic proximity Read

Heterogeneity of Cholangiocarcinoma Immune BiologySemantic proximity Read

Selective Targeting uPAR-driven Neutrophil Extracellular Traps Functional Clusters to Attenuate Tumor Progression and Enhance the Response to Immunotherapy in Intrahepatic CholangiocarcinomaSemantic proximity Read

Expression pattern of cancer-associated fibroblast and its clinical relevance in intrahepatic cholangiocarcinoma.Semantic proximity Read

Single Cell Analysis of Cultivated Fibroblasts from Chronic Pancreatitis and Pancreatic Cancer PatientsSemantic proximity Read

Identifying Telomere-Related Genes as Prognostic Biomarkers of Cholangiocarcinoma and Exploring Their Biological Functions Based on Integrated Analysis of Single-Cell and Bulk RNA Sequencing DataSemantic proximity Read