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CXCL12 derived from cancer-associated fibroblasts mediates dysfunctional intratumoral adaptive immunity in diabetic pancreatic adenocarcinoma

2025-09-09

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Diabetes mellitus (DM) affects the occurrence and progression of pancreatic adenocarcinoma (PAAD), but the DM-related immune characteristic in PAAD remains unclear. This study aimed to elucidate the immune landscape and underlying mechanism in diabetic PAAD. <bold>Methods</bold> RNA-sequencing data from primary sorted cancer-associated fibroblasts (CAFs) and...

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Literature Corpus work
adce231a-8444-5426-9e50-f651aec3cfae
DOI
10.21203/rs.3.rs-7429791/v1
Open publication

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CXCL12 derived from cancer-associated fibroblasts mediates dysfunctional intratumoral adaptive immunity in diabetic pancreatic adenocarcinomaDOI 10.21203/rs.3.rs-7429791/v1
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