Article

“Tumor-to-endothelium mitochondrial transfer licenses endothelial cells for CD8 <sup>+</sup> T cell recognition via mitochondrial neoantigen presentation”

2026-02-02

Abstract excerpt

Renal cell carcinoma (RCC) frequently exhibits resistance to immune checkpoint blockade, highlighting the need for strategies that enhance tumor-specific T cell priming and improve immune access to the tumor microenvironment. Here we show that vaccination targeting tumor-associated mitochondrial antigens (TAMAs), derived from tumor-specific mitochondrial DNA (mtDNA) missense mutations, synergizes with PD-1/PD-L1 b...

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Literature Corpus work: 6f5ff1d8-8759-5452-a824-1e46ab19ba23
DOI: 10.64898/2026.01.30.702567

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