Article

Role of excitotoxicity in the degeneration of motor neurones in ALS

2005-01-01

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder involving selective degeneration of motor neurones. In a proportion of patients, ALS is caused by mutations in copper/zinc superoxide dismutase (SOD1), and mice expressing these mutants develop a syndrome that resembles human ALS. Using SOD1<sup>G93A</sup> transgenic mice, the role of glutamate-mediated toxicity and related intracellular pathways...

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Literature Corpus work: 6f5f5bfe-d721-51ff-98df-1008df49f578
DOI: 10.21954/ou.ro.000101b2

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